Assay Detail
Binding
CHEMBL989641
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Inhibition of human recombinant indoleamine 2,3-dioxygenase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.22 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468547 | EXIGUAMINE A | — | 1 | 7.39 |
| CHEMBL518688 | ANNULIN C | — | 1 | 6.85 |
| CHEMBL500863 | — | — | 1 | 6.72 |
| CHEMBL467137 | — | — | 1 | 6.70 |
| CHEMBL466151 | — | — | 1 | 6.58 |
| CHEMBL512428 | — | — | 1 | 6.58 |
| CHEMBL466932 | — | — | 1 | 6.38 |
| CHEMBL510240 | — | — | 1 | 5.83 |
| CHEMBL449842 | — | — | 1 | 4.96 |
| CHEMBL513172 | 1-METHYLTRYPTOPHAN | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468547 | EXIGUAMINE A | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL518688 | ANNULIN C | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL500863 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL467137 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL466151 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL512428 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL466932 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL510240 | — | Ki | = | 1490.0 | nM | 5.83 |
| CHEMBL449842 | — | Ki | = | 10900.0 | nM | 4.96 |
| CHEMBL513172 | 1-METHYLTRYPTOPHAN | Ki | = | 62000.0 | nM | 4.21 |