Assay Detail
Functional
CHEMBL989659
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum 3D7A infected erythrocytes by [3H]hypoxanthine uptake
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.45 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.57 |
| CHEMBL467584 | — | — | 1 | 8.30 |
| CHEMBL469011 | — | — | 1 | 8.30 |
| CHEMBL444503 | — | — | 1 | 8.15 |
| CHEMBL512802 | — | — | 1 | 8.10 |
| CHEMBL468638 | — | — | 1 | 7.52 |
| CHEMBL468637 | — | — | 1 | 7.52 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 7.51 |
| CHEMBL511932 | — | — | 1 | 6.96 |
| CHEMBL467583 | — | — | 1 | 6.80 |
| CHEMBL468343 | — | — | 1 | 6.70 |
| CHEMBL468639 | — | — | 1 | 6.52 |
| CHEMBL513164 | — | — | 1 | 6.40 |
| CHEMBL468990 | — | — | 1 | 5.89 |
| CHEMBL513677 | — | — | 1 | - |
| CHEMBL468344 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL467584 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL469011 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL444503 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL512802 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL468638 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL468637 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL511932 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL467583 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL468343 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL468639 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL513164 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL468990 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL513677 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL468344 | — | IC50 | > | 1000.0 | nM | - |