Assay Detail
Functional
CHEMBL989660
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Antimalarial activity against Plasmodium falciparum FCR3-A infected erythrocytes as [3H]hypoxanthine incorporation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.50 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL467584 | — | — | 1 | 9.00 |
| CHEMBL469011 | — | — | 1 | 8.60 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 6.52 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL467584 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL469011 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 1360.0 | nM | 5.87 |