Assay Detail
Functional
CHEMBL989664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxic activity against human NCI-H460 cells after 72 hrs by sulforhodamine B test
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of fluorinated combretastatin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.87 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL467598 | — | — | 1 | 8.96 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.91 |
| CHEMBL468194 | — | — | 1 | 8.62 |
| CHEMBL468580 | — | — | 1 | 8.52 |
| CHEMBL468629 | — | — | 1 | 8.40 |
| CHEMBL330407 | — | — | 1 | 8.31 |
| CHEMBL468014 | — | — | 1 | 8.14 |
| CHEMBL466357 | — | — | 1 | 7.94 |
| CHEMBL468647 | — | — | 1 | 7.37 |
| CHEMBL192224 | — | — | 1 | 6.89 |
| CHEMBL468998 | — | — | 1 | 6.42 |
| CHEMBL467780 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL467598 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.24 | nM | 8.91 |
| CHEMBL468194 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL468580 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL468629 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL330407 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL468014 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL466357 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL468647 | — | IC50 | = | 42.6 | nM | 7.37 |
| CHEMBL192224 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL468998 | — | IC50 | = | 379.0 | nM | 6.42 |
| CHEMBL467780 | — | IC50 | = | 1166.0 | nM | 5.93 |