Assay Detail
Binding
CHEMBL989727
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Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma vivax |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 4.82 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261634 | IMINORIBITOL | — | 1 | 5.21 |
| CHEMBL495396 | — | — | 1 | 5.17 |
| CHEMBL505234 | — | — | 1 | 5.16 |
| CHEMBL486805 | — | — | 1 | 4.75 |
| CHEMBL443359 | — | — | 1 | 4.40 |
| CHEMBL1169558 | — | — | 1 | 4.23 |
| CHEMBL495460 | — | — | 1 | - |
| CHEMBL446539 | — | — | 1 | - |
| CHEMBL231630 | — | — | 1 | - |
| CHEMBL448265 | — | — | 1 | - |
| CHEMBL450920 | — | — | 1 | - |
| CHEMBL493608 | — | — | 1 | - |
| CHEMBL495042 | — | — | 1 | - |
| CHEMBL455563 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261634 | IMINORIBITOL | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL495396 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL505234 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL486805 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL443359 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL1169558 | — | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL495460 | — | Ki | = | 1283000.0 | nM | - |
| CHEMBL446539 | — | Ki | = | 545000.0 | nM | - |
| CHEMBL231630 | — | Ki | = | 5640000.0 | nM | - |
| CHEMBL448265 | — | Ki | = | 309000.0 | nM | - |
| CHEMBL450920 | — | Ki | = | 685000.0 | nM | - |
| CHEMBL493608 | — | Ki | = | 677000.0 | nM | - |
| CHEMBL495042 | — | Ki | = | 286000.0 | nM | - |
| CHEMBL455563 | — | Ki | = | 4500000.0 | nM | - |