Assay Detail
Binding
CHEMBL989748
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Displacement of [3H]Spiperone from human 5HT2A receptor expressed in HEK293 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.04 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478671 | — | — | 1 | 7.25 |
| CHEMBL255229 | — | — | 1 | 7.14 |
| CHEMBL403550 | — | — | 1 | 7.04 |
| CHEMBL516580 | — | — | 1 | 7.02 |
| CHEMBL515342 | — | — | 1 | 6.96 |
| CHEMBL515187 | — | — | 1 | 6.96 |
| CHEMBL27559 | — | — | 1 | 6.94 |
| CHEMBL509451 | — | — | 1 | - |
| CHEMBL455318 | — | — | 1 | - |
| CHEMBL478043 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478671 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL255229 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL403550 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL516580 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL515342 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL515187 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL27559 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL509451 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL455318 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL478043 | — | Ki | > | 10000.0 | nM | - |