Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL989823

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting
ChEMBL ↗
91
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors.
Zheng S, Kaur G, Wang H, Li M, Macnaughtan M, Yang X, Reid S, Prestegard J, Wang B, Ke H.
J Med Chem (2008) 51 : 7673 -7688
PubMed 19049349 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 91 5.68 7.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL458298 — — 2 7.74
CHEMBL511686 — — 2 7.66
CHEMBL45834 — — 1 7.55
CHEMBL508134 — — 2 7.21
CHEMBL47113 — — 1 7.15
CHEMBL456591 — — 2 6.75
CHEMBL457663 — — 2 6.75
CHEMBL517124 — — 1 6.70
CHEMBL456573 — — 2 6.70
CHEMBL458297 — — 2 6.46
CHEMBL457215 — — 2 6.42
CHEMBL45055 — — 1 6.40
CHEMBL456574 — — 2 6.40
CHEMBL456590 — — 2 6.39
CHEMBL456617 — — 2 6.30
CHEMBL63 ROLIPRAM 2.0 2 6.26
CHEMBL458933 — — 2 6.20
CHEMBL45854 — — 1 6.19
CHEMBL458932 — — 2 6.18
CHEMBL443679 — — 2 6.14
CHEMBL457662 — — 2 5.96
CHEMBL298000 — — 1 5.80
CHEMBL456327 — — 2 5.72
CHEMBL458931 — — 2 5.66
CHEMBL516301 — — 2 5.64
CHEMBL513099 — — 2 5.59
CHEMBL460188 — — 2 5.59
CHEMBL44109 — — 1 5.51
CHEMBL456368 — — 2 5.46
CHEMBL456618 — — 2 5.28

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL458298 — IC50 = 18.2 nM 7.74
CHEMBL511686 — IC50 = 21.88 nM 7.66
CHEMBL458298 — IC50 = 26.0 nM 7.58
CHEMBL45834 — IC50 = 28.18 nM 7.55
CHEMBL511686 — IC50 = 28.0 nM 7.55
CHEMBL508134 — IC50 = 61.66 nM 7.21
CHEMBL508134 — IC50 = 61.0 nM 7.21
CHEMBL47113 — IC50 = 70.79 nM 7.15
CHEMBL457663 — IC50 = 180.0 nM 6.75
CHEMBL456591 — IC50 = 177.83 nM 6.75
CHEMBL457663 — IC50 = 181.97 nM 6.74
CHEMBL456591 — IC50 = 190.0 nM 6.72
CHEMBL517124 — IC50 = 199.53 nM 6.70
CHEMBL456573 — IC50 = 199.53 nM 6.70
CHEMBL456573 — IC50 = 220.0 nM 6.66
CHEMBL458297 — IC50 = 346.74 nM 6.46
CHEMBL458297 — IC50 = 350.0 nM 6.46
CHEMBL457215 — IC50 = 380.0 nM 6.42
CHEMBL457215 — IC50 = 380.19 nM 6.42
CHEMBL45055 — IC50 = 398.11 nM 6.40
CHEMBL456574 — IC50 = 398.11 nM 6.40
CHEMBL456590 — IC50 = 407.38 nM 6.39
CHEMBL456590 — IC50 = 410.0 nM 6.39
CHEMBL456574 — IC50 = 430.0 nM 6.37
CHEMBL456617 — IC50 = 501.19 nM 6.30
CHEMBL63 ROLIPRAM IC50 = 549.54 nM 6.26
CHEMBL63 ROLIPRAM IC50 = 550.0 nM 6.26
CHEMBL458933 — IC50 = 636.0 nM 6.20
CHEMBL458933 — IC50 = 630.96 nM 6.20
CHEMBL45854 — IC50 = 645.65 nM 6.19
CHEMBL458932 — IC50 = 667.0 nM 6.18
CHEMBL458932 — IC50 = 660.69 nM 6.18
CHEMBL443679 — IC50 = 720.0 nM 6.14
CHEMBL443679 — IC50 = 724.44 nM 6.14
CHEMBL456617 — IC50 = 820.0 nM 6.09
CHEMBL457662 — IC50 = 1096.48 nM 5.96
CHEMBL457662 — IC50 = 1100.0 nM 5.96
CHEMBL298000 — IC50 = 1584.89 nM 5.80
CHEMBL456327 — IC50 = 1905.46 nM 5.72
CHEMBL456327 — IC50 = 1900.0 nM 5.72
CHEMBL458931 — IC50 = 2187.76 nM 5.66
CHEMBL458931 — IC50 = 2200.0 nM 5.66
CHEMBL516301 — IC50 = 2290.87 nM 5.64
CHEMBL460188 — IC50 = 2570.4 nM 5.59
CHEMBL513099 — IC50 = 2570.4 nM 5.59
CHEMBL513099 — IC50 = 2600.0 nM 5.58
CHEMBL460188 — IC50 = 2600.0 nM 5.58
CHEMBL44109 — IC50 = 3090.3 nM 5.51
CHEMBL456368 — IC50 = 3500.0 nM 5.46
CHEMBL456368 — IC50 = 3467.37 nM 5.46