Assay Detail
Functional
CHEMBL989842
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Inhibition of human placental CYP19
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.33 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 7.52 |
| CHEMBL362968 | — | — | 1 | 6.22 |
| CHEMBL365735 | — | — | 1 | 5.24 |
| CHEMBL196796 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL362968 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL365735 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL196796 | — | IC50 | > | 36000.0 | nM | - |