Assay Detail
Binding
CHEMBL989869
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Inhibition of verapamil-induced ATPase activity in lipid activated mouse P-glycoprotein mdr3 cys-less mutant assessed as ATP hydrolysis per ug of protein
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chalcogenopyrylium dyes as inhibitors/modulators of P-glycoprotein in multidrug-resistant cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.23 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462522 | — | — | 1 | 6.16 |
| CHEMBL229938 | — | — | 1 | 6.06 |
| CHEMBL229403 | — | — | 1 | 6.00 |
| CHEMBL457023 | — | — | 1 | 5.92 |
| CHEMBL457869 | — | — | 1 | 5.51 |
| CHEMBL461674 | — | — | 1 | 5.28 |
| CHEMBL461672 | — | — | 1 | 5.24 |
| CHEMBL461671 | — | — | 1 | 5.10 |
| CHEMBL148507 | — | — | 1 | 4.96 |
| CHEMBL229402 | — | — | 1 | 4.82 |
| CHEMBL514092 | — | — | 1 | 4.52 |
| CHEMBL515523 | — | — | 1 | 4.26 |
| CHEMBL457022 | — | — | 1 | 4.15 |
| CHEMBL460395 | — | — | 1 | - |
| CHEMBL229404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462522 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL229938 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL229403 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL457023 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL457869 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL461674 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL461672 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL461671 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL148507 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL229402 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL514092 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL515523 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL457022 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL460395 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL229404 | — | IC50 | > | 100000.0 | nM | - |