Assay Detail
Functional
CHEMBL989874
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Enhancement of calcein-AM uptake in MDCK2 cells over expressing MDR1 after 20 mins
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Cell Type | MDCK-II |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chalcogenopyrylium dyes as inhibitors/modulators of P-glycoprotein in multidrug-resistant cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.93 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 5.29 |
| CHEMBL457023 | — | — | 1 | 5.27 |
| CHEMBL436099 | — | — | 1 | 5.17 |
| CHEMBL229938 | — | — | 1 | 5.15 |
| CHEMBL229404 | — | — | 1 | 5.01 |
| CHEMBL461674 | — | — | 1 | 4.85 |
| CHEMBL229402 | — | — | 1 | 4.80 |
| CHEMBL460394 | — | — | 1 | 4.70 |
| CHEMBL460395 | — | — | 1 | 4.60 |
| CHEMBL462522 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL457023 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL436099 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL229938 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL229404 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL461674 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL229402 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL460394 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL460395 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL462522 | — | EC50 | = | 35000.0 | nM | 4.46 |