Assay Detail
Binding
CHEMBL989971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cRAF
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.10 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476141 | — | — | 1 | 7.10 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476141 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | >= | 1000.0 | nM | - |