Assay Detail
Functional
CHEMBL989986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay
69
Total Activities
69
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity correlations for beta-phenethylamines at human trace amine receptor 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 68 | 5.90 | 7.29 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510649 | — | — | 1 | 7.29 |
| CHEMBL447753 | — | — | 1 | 7.24 |
| CHEMBL379916 | — | — | 1 | 7.19 |
| CHEMBL407939 | — | — | 1 | 7.11 |
| CHEMBL476517 | — | — | 1 | 6.99 |
| CHEMBL443141 | — | — | 1 | 6.93 |
| CHEMBL610 | PHENETHYLAMINE | — | 1 | 6.89 |
| CHEMBL448232 | — | — | 1 | 6.89 |
| CHEMBL100635 | — | — | 1 | 6.84 |
| CHEMBL446238 | — | — | 1 | 6.82 |
| CHEMBL453667 | — | — | 1 | 6.80 |
| CHEMBL274497 | — | — | 1 | 6.72 |
| CHEMBL478847 | — | — | 1 | 6.69 |
| CHEMBL452901 | — | — | 1 | 6.51 |
| CHEMBL451372 | — | — | 1 | 6.45 |
| CHEMBL508991 | — | — | 1 | 6.44 |
| CHEMBL509695 | — | — | 1 | 6.42 |
| CHEMBL45763 | — | — | 1 | 6.41 |
| CHEMBL505644 | — | — | 1 | 6.40 |
| CHEMBL130703 | — | — | 1 | 6.30 |
| CHEMBL446131 | — | — | 1 | 6.28 |
| CHEMBL367501 | — | — | 1 | 6.21 |
| CHEMBL448576 | — | — | 1 | 6.20 |
| CHEMBL478845 | — | — | 1 | 6.16 |
| CHEMBL11608 | TYRAMINE | 3.0 | 1 | 6.14 |
| CHEMBL217315 | — | — | 1 | 6.13 |
| CHEMBL450477 | — | — | 1 | 6.12 |
| CHEMBL19393 | LEVAMFETAMINE | 4.0 | 1 | 6.04 |
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 6.03 |
| CHEMBL476324 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510649 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL447753 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL379916 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL407939 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL476517 | — | EC50 | = | 103.0 | nM | 6.99 |
| CHEMBL443141 | — | EC50 | = | 117.0 | nM | 6.93 |
| CHEMBL610 | PHENETHYLAMINE | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL448232 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL100635 | — | EC50 | = | 144.0 | nM | 6.84 |
| CHEMBL446238 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL453667 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL274497 | — | EC50 | = | 189.0 | nM | 6.72 |
| CHEMBL478847 | — | EC50 | = | 205.0 | nM | 6.69 |
| CHEMBL452901 | — | EC50 | = | 312.0 | nM | 6.51 |
| CHEMBL451372 | — | EC50 | = | 355.0 | nM | 6.45 |
| CHEMBL508991 | — | EC50 | = | 361.0 | nM | 6.44 |
| CHEMBL509695 | — | EC50 | = | 377.0 | nM | 6.42 |
| CHEMBL45763 | — | EC50 | = | 387.0 | nM | 6.41 |
| CHEMBL505644 | — | EC50 | = | 398.0 | nM | 6.40 |
| CHEMBL130703 | — | EC50 | = | 501.0 | nM | 6.30 |
| CHEMBL446131 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL367501 | — | EC50 | = | 614.0 | nM | 6.21 |
| CHEMBL448576 | — | EC50 | = | 638.0 | nM | 6.20 |
| CHEMBL478845 | — | EC50 | = | 687.0 | nM | 6.16 |
| CHEMBL11608 | TYRAMINE | EC50 | = | 731.0 | nM | 6.14 |
| CHEMBL217315 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL450477 | — | EC50 | = | 767.0 | nM | 6.12 |
| CHEMBL19393 | LEVAMFETAMINE | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL612 | DEXTROAMPHETAMINE | EC50 | = | 935.0 | nM | 6.03 |
| CHEMBL476324 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL476750 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL442603 | — | EC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL449727 | — | EC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL509223 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL316698 | — | EC50 | = | 1444.0 | nM | 5.84 |
| CHEMBL1179 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL476516 | — | EC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL145584 | — | EC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL287047 | — | EC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL477764 | — | EC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL10780 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL147230 | — | EC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL506244 | — | EC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL124733 | — | EC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL448523 | — | EC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL450561 | — | EC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL103299 | — | EC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL420095 | — | EC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL61251 | — | EC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL1574 | PHENTERMINE | EC50 | = | 5470.0 | nM | 5.26 |