Assay Detail
Functional
CHEMBL990136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.31 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481283 | — | — | 1 | 9.52 |
| CHEMBL520097 | — | — | 1 | 8.92 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.66 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.94 |
| CHEMBL186106 | — | — | 1 | 7.75 |
| CHEMBL479751 | — | — | 1 | 7.38 |
| CHEMBL511986 | — | — | 1 | 7.05 |
| CHEMBL363956 | — | — | 1 | 6.68 |
| CHEMBL519104 | — | — | 1 | 6.64 |
| CHEMBL479750 | — | — | 1 | 6.46 |
| CHEMBL470928 | — | — | 1 | 6.43 |
| CHEMBL480118 | — | — | 1 | 6.43 |
| CHEMBL518460 | — | — | 1 | 6.24 |
| CHEMBL470748 | — | — | 1 | 6.22 |
| CHEMBL479553 | — | — | 1 | - |
| CHEMBL89310 | — | — | 1 | - |
| CHEMBL479930 | — | — | 1 | - |
| CHEMBL480117 | — | — | 1 | - |
| CHEMBL517372 | — | — | 1 | - |
| CHEMBL479744 | — | — | 1 | - |
| CHEMBL481282 | — | — | 1 | - |
| CHEMBL521095 | — | — | 1 | - |
| CHEMBL480702 | — | — | 1 | - |
| CHEMBL481087 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481283 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL520097 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL107 | COLCHICINE | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL186106 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL479751 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL511986 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL363956 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL519104 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL479750 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL470928 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL480118 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL518460 | — | IC50 | = | 575.0 | nM | 6.24 |
| CHEMBL470748 | — | IC50 | = | 596.0 | nM | 6.22 |
| CHEMBL479553 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL89310 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL479930 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL480117 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL517372 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL479744 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL481282 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL521095 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL480702 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL481087 | — | IC50 | > | 5000.0 | nM | - |