Assay Detail
Functional
CHEMBL990138
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Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.33 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481283 | — | — | 1 | 9.22 |
| CHEMBL520097 | — | — | 1 | 8.51 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.25 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.96 |
| CHEMBL186106 | — | — | 1 | 7.77 |
| CHEMBL479751 | — | — | 1 | 7.39 |
| CHEMBL511986 | — | — | 1 | 7.28 |
| CHEMBL519104 | — | — | 1 | 7.00 |
| CHEMBL479750 | — | — | 1 | 6.81 |
| CHEMBL363956 | — | — | 1 | 6.70 |
| CHEMBL470928 | — | — | 1 | 6.59 |
| CHEMBL480118 | — | — | 1 | 6.50 |
| CHEMBL470748 | — | — | 1 | 6.40 |
| CHEMBL518460 | — | — | 1 | 6.28 |
| CHEMBL479553 | — | — | 1 | - |
| CHEMBL89310 | — | — | 1 | - |
| CHEMBL479930 | — | — | 1 | - |
| CHEMBL480117 | — | — | 1 | - |
| CHEMBL517372 | — | — | 1 | - |
| CHEMBL479744 | — | — | 1 | - |
| CHEMBL481282 | — | — | 1 | - |
| CHEMBL521095 | — | — | 1 | - |
| CHEMBL480702 | — | — | 1 | - |
| CHEMBL481087 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481283 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL520097 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL107 | COLCHICINE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL186106 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL479751 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL511986 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL519104 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL479750 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL363956 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL470928 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL480118 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL470748 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL518460 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL479553 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL89310 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL479930 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL480117 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL517372 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL479744 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL481282 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL521095 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL480702 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL481087 | — | IC50 | > | 5000.0 | nM | - |