Assay Detail
Functional
CHEMBL990243
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Cytotoxicity against human LoVo cells
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.92 | 10.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | 2.0 | 2 | 10.18 |
| CHEMBL501233 | SYMPLOSTATIN 1 | — | 1 | 9.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | IC50 | = | 0.066 | nM | 10.18 |
| CHEMBL39541 | DOLASTATIN-10 | IC50 | = | 0.076 | nM | 10.12 |
| CHEMBL501233 | SYMPLOSTATIN 1 | IC50 | = | 0.34 | nM | 9.47 |