Assay Detail
ADMET
CHEMBL990364
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Antiproliferative activity against HFF after 72 hrs by MEB assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.25 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473436 | — | — | 1 | 5.62 |
| CHEMBL475769 | — | — | 1 | 5.10 |
| CHEMBL473428 | — | — | 1 | 5.03 |
| CHEMBL474431 | — | — | 1 | - |
| CHEMBL475600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473436 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL475769 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL473428 | — | IC50 | = | 9390.0 | nM | 5.03 |
| CHEMBL474431 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL475600 | — | IC50 | > | 3000.0 | nM | - |