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Assay Detail

CHEMBL990582

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Binding
Inhibition of JNK1
ChEMBL ↗
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Mitogen-activated protein kinase 8 (CHEMBL2276) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3D-QSAR and docking studies of aminopyridine carboxamide inhibitors of c-Jun N-terminal kinase-1.
Yi P, Qiu M.
Eur J Med Chem (2008) 43 : 604 -613
PubMed 17602798 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 54 6.53 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL220504 — — 1 7.82
CHEMBL495233 — — 1 7.66
CHEMBL374269 — — 1 7.64
CHEMBL220658 — — 1 7.50
CHEMBL374193 — — 1 7.37
CHEMBL221126 — — 1 7.32
CHEMBL434560 — — 1 7.27
CHEMBL386010 — — 1 7.23
CHEMBL221315 — — 1 7.18
CHEMBL218194 — — 1 7.17
CHEMBL384219 — — 1 7.12
CHEMBL221128 — — 1 7.10
CHEMBL219112 — — 1 7.09
CHEMBL221229 — — 1 7.07
CHEMBL218658 — — 1 7.06
CHEMBL218219 — — 1 7.03
CHEMBL220810 — — 1 7.03
CHEMBL375795 — — 1 7.02
CHEMBL384951 — — 1 6.92
CHEMBL218657 — — 1 6.82
CHEMBL218141 — — 1 6.77
CHEMBL221227 — — 1 6.75
CHEMBL221745 — — 1 6.70
CHEMBL218367 — — 1 6.60
CHEMBL220758 — — 1 6.58
CHEMBL387253 — — 1 6.57
CHEMBL434368 — — 1 6.52
CHEMBL220811 — — 1 6.50
CHEMBL221179 — — 1 6.50
CHEMBL383994 — — 1 6.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL220504 — IC50 = 15.0 nM 7.82
CHEMBL495233 — IC50 = 21.98 nM 7.66
CHEMBL374269 — IC50 = 23.01 nM 7.64
CHEMBL220658 — IC50 = 31.99 nM 7.50
CHEMBL374193 — IC50 = 42.95 nM 7.37
CHEMBL221126 — IC50 = 47.97 nM 7.32
CHEMBL434560 — IC50 = 53.95 nM 7.27
CHEMBL386010 — IC50 = 59.02 nM 7.23
CHEMBL221315 — IC50 = 66.07 nM 7.18
CHEMBL218194 — IC50 = 66.99 nM 7.17
CHEMBL384219 — IC50 = 76.03 nM 7.12
CHEMBL221128 — IC50 = 79.07 nM 7.10
CHEMBL219112 — IC50 = 80.91 nM 7.09
CHEMBL221229 — IC50 = 84.92 nM 7.07
CHEMBL218658 — IC50 = 87.9 nM 7.06
CHEMBL218219 — IC50 = 92.9 nM 7.03
CHEMBL220810 — IC50 = 92.9 nM 7.03
CHEMBL375795 — IC50 = 95.94 nM 7.02
CHEMBL384951 — IC50 = 119.95 nM 6.92
CHEMBL218657 — IC50 = 149.97 nM 6.82
CHEMBL218141 — IC50 = 169.82 nM 6.77
CHEMBL221227 — IC50 = 179.89 nM 6.75
CHEMBL221745 — IC50 = 199.99 nM 6.70
CHEMBL218367 — IC50 = 250.03 nM 6.60
CHEMBL220758 — IC50 = 260.02 nM 6.58
CHEMBL387253 — IC50 = 269.77 nM 6.57
CHEMBL434368 — IC50 = 299.92 nM 6.52
CHEMBL220811 — IC50 = 319.89 nM 6.50
CHEMBL221179 — IC50 = 317.69 nM 6.50
CHEMBL383994 — IC50 = 349.95 nM 6.46
CHEMBL374431 — IC50 = 389.94 nM 6.41
CHEMBL220865 — IC50 = 410.2 nM 6.39
CHEMBL218419 — IC50 = 419.76 nM 6.38
CHEMBL220812 — IC50 = 429.54 nM 6.37
CHEMBL221252 — IC50 = 429.54 nM 6.37
CHEMBL374447 — IC50 = 529.66 nM 6.28
CHEMBL220547 — IC50 = 570.16 nM 6.24
CHEMBL221075 — IC50 = 619.44 nM 6.21
CHEMBL220749 — IC50 = 820.35 nM 6.09
CHEMBL221963 — IC50 = 1088.93 nM 5.96
CHEMBL221916 — IC50 = 1180.32 nM 5.93
CHEMBL222008 — IC50 = 1180.32 nM 5.93
CHEMBL385177 — IC50 = 1448.77 nM 5.84
CHEMBL495459 — IC50 = 1499.68 nM 5.82
CHEMBL373740 — IC50 = 1548.82 nM 5.81
CHEMBL218139 — IC50 = 1599.56 nM 5.80
CHEMBL495406 — IC50 = 1640.59 nM 5.79
CHEMBL220607 — IC50 = 1990.67 nM 5.70
CHEMBL376096 — IC50 = 2238.72 nM 5.65
CHEMBL374795 — IC50 = 2432.2 nM 5.61