Assay Detail
Binding
CHEMBL990612
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Displacement of [3H]5HT from human cloned 5HT1B receptor expressed in CHO cells
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.33 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490417 | — | — | 1 | 9.30 |
| CHEMBL483365 | — | — | 1 | 8.20 |
| CHEMBL183460 | — | — | 1 | 8.00 |
| CHEMBL485427 | — | — | 1 | 7.60 |
| CHEMBL484216 | — | — | 2 | 7.40 |
| CHEMBL485395 | — | — | 1 | 7.30 |
| CHEMBL484387 | — | — | 1 | 7.30 |
| CHEMBL484386 | — | — | 1 | 6.70 |
| CHEMBL519010 | — | — | 1 | 6.50 |
| CHEMBL519019 | — | — | 1 | 6.40 |
| CHEMBL485630 | — | — | 1 | 6.20 |
| CHEMBL484205 | — | — | 1 | - |
| CHEMBL484742 | — | — | 1 | - |
| CHEMBL484743 | — | — | 1 | - |
| CHEMBL519037 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490417 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL483365 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL183460 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL485427 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL484216 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL485395 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL484387 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL484216 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL484386 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL519010 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL519019 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL485630 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL484205 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL484742 | — | Ki | > | 2511.89 | nM | - |
| CHEMBL484743 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL519037 | — | Ki | > | 5011.87 | nM | - |