Assay Detail
Binding
CHEMBL990633
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Inhibition of HIV1 protease
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of sulfoximine based inhibitors for HIV-1 protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.15 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 9.40 |
| CHEMBL109952 | — | — | 1 | 9.22 |
| CHEMBL1627210 | — | — | 1 | 8.60 |
| CHEMBL1627209 | — | — | 1 | 7.68 |
| CHEMBL1627246 | — | — | 1 | 4.00 |
| CHEMBL1627244 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5483011 | INDINAVIR | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL109952 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1627210 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1627209 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1627246 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1627244 | — | IC50 | = | 100000.0 | nM | 4.00 |