Assay Detail
Functional
CHEMBL990648
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania donovani MHOM/SD/62/1S-CL2D axenic amastigotes
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 4.99 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354342 | — | — | 1 | 6.00 |
| CHEMBL485235 | — | — | 1 | 5.82 |
| CHEMBL485410 | — | — | 1 | 5.80 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.75 |
| CHEMBL485417 | — | — | 1 | 5.75 |
| CHEMBL447285 | — | — | 1 | 5.75 |
| CHEMBL520518 | — | — | 1 | 5.70 |
| CHEMBL520013 | — | — | 1 | 5.52 |
| CHEMBL500330 | — | — | 1 | 5.51 |
| CHEMBL485439 | — | — | 1 | 5.44 |
| CHEMBL443628 | — | — | 1 | 5.43 |
| CHEMBL520654 | — | — | 1 | 5.35 |
| CHEMBL449450 | — | — | 1 | 5.28 |
| CHEMBL442644 | — | — | 1 | 5.24 |
| CHEMBL484737 | — | — | 1 | 5.24 |
| CHEMBL485423 | — | — | 1 | 5.24 |
| CHEMBL483399 | — | — | 1 | 5.24 |
| CHEMBL484548 | — | — | 1 | 5.13 |
| CHEMBL506885 | — | — | 1 | 4.92 |
| CHEMBL458546 | — | — | 1 | 4.89 |
| CHEMBL483571 | — | — | 1 | 4.89 |
| CHEMBL485224 | — | — | 1 | 4.85 |
| CHEMBL484351 | — | — | 1 | 4.85 |
| CHEMBL484194 | — | — | 1 | 4.82 |
| CHEMBL485573 | — | — | 1 | 4.80 |
| CHEMBL484195 | — | — | 1 | 4.70 |
| CHEMBL520186 | — | — | 1 | 4.70 |
| CHEMBL353802 | — | — | 1 | 4.68 |
| CHEMBL483572 | — | — | 1 | 4.62 |
| CHEMBL484181 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354342 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL485235 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL485410 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL485417 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL447285 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL520518 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL520013 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL500330 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL485439 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL443628 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL520654 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL449450 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL485423 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL484737 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL442644 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL483399 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL484548 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL506885 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL458546 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL483571 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL485224 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL484351 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL484194 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL485573 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL484195 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL520186 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL353802 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL483572 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL484181 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL520335 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL464397 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL519519 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL518085 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL458959 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL464601 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL485424 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL511688 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL485225 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL464396 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL520143 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL521501 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL485438 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL520485 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL456434 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL520807 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL451356 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL485414 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL448231 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL484563 | — | IC50 | > | 50000.0 | nM | - |