Assay Detail
Binding
CHEMBL991024
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Inhibition of Staphylococcus aureus MetRS assessed as decrease in [32S]methionine incorporation by SPA
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of novel inhibitors of methionyl-tRNA synthetase (MetRS) by virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.30 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157867 | — | — | 1 | 8.10 |
| CHEMBL518960 | — | — | 1 | 7.70 |
| CHEMBL57382 | — | — | 1 | 7.16 |
| CHEMBL518453 | — | — | 1 | 6.89 |
| CHEMBL481857 | — | — | 1 | 6.68 |
| CHEMBL519102 | — | — | 1 | 6.24 |
| CHEMBL479368 | — | — | 1 | 5.32 |
| CHEMBL481101 | — | — | 1 | 5.24 |
| CHEMBL481670 | — | — | 1 | 5.20 |
| CHEMBL481102 | — | — | 1 | 5.08 |
| CHEMBL479768 | — | — | 1 | 4.94 |
| CHEMBL479954 | — | — | 1 | 4.63 |
| CHEMBL471961 | — | — | 1 | 4.60 |
| CHEMBL509431 | — | — | 1 | 4.58 |
| CHEMBL479769 | — | — | 1 | 4.45 |
| CHEMBL479953 | — | — | 1 | 4.39 |
| CHEMBL516453 | — | — | 1 | 4.38 |
| CHEMBL517071 | — | — | 1 | 4.33 |
| CHEMBL479369 | — | — | 1 | 4.33 |
| CHEMBL471955 | — | — | 1 | 4.25 |
| CHEMBL512366 | — | — | 1 | 4.06 |
| CHEMBL450662 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157867 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL518960 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL57382 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL518453 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL481857 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL519102 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL479368 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL481101 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL481670 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL481102 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL479768 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL479954 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL471961 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL509431 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL479769 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL479953 | — | IC50 | = | 40800.0 | nM | 4.39 |
| CHEMBL516453 | — | IC50 | = | 41700.0 | nM | 4.38 |
| CHEMBL517071 | — | IC50 | = | 46300.0 | nM | 4.33 |
| CHEMBL479369 | — | IC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL471955 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL512366 | — | IC50 | = | 86800.0 | nM | 4.06 |
| CHEMBL450662 | — | IC50 | = | 94900.0 | nM | 4.02 |