Assay Detail
Binding
CHEMBL991027
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Inhibition of HSV1 DNA polymerase by scintillation proximity assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
DNA polymerase catalytic subunit (CHEMBL5944) ↗| Type | SINGLE PROTEIN |
| Organism | Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus1) |
Publication
Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.24 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481172 | — | — | 1 | 6.66 |
| CHEMBL479371 | — | — | 1 | 6.46 |
| CHEMBL29711 | APHIDICOLIN | — | 1 | 6.36 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 5.48 |
| CHEMBL666 | FOSCARNET | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481172 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL479371 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 438.0 | nM | 6.36 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL666 | FOSCARNET | IC50 | - | — | - |