Assay Detail
Binding
CHEMBL991179
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HMGCoA reductase
13
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.86 | 8.70 |
| Ki | 1 | 9.22 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503 | LOVASTATIN | 4.0 | 2 | 9.22 |
| CHEMBL489540 | — | — | 1 | 6.30 |
| CHEMBL504781 | — | — | 1 | 5.82 |
| CHEMBL482803 | — | — | 1 | 5.70 |
| CHEMBL482601 | — | — | 1 | 5.52 |
| CHEMBL501307 | — | — | 1 | 5.52 |
| CHEMBL485858 | — | — | 1 | 5.30 |
| CHEMBL482804 | — | — | 1 | 5.30 |
| CHEMBL483819 | — | — | 1 | 5.30 |
| CHEMBL448462 | — | — | 1 | 5.16 |
| CHEMBL46403 | STEARIC ACID | -1.0 | 1 | - |
| CHEMBL8659 | OLEIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503 | LOVASTATIN | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL489540 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL504781 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL482803 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL482601 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL501307 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL485858 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL482804 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL483819 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL448462 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL46403 | STEARIC ACID | IC50 | - | — | - | |
| CHEMBL8659 | OLEIC ACID | IC50 | - | — | - |