Assay Detail
Binding
CHEMBL991389
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from 5HT2A receptor expressed in HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.43 | 8.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458002 | — | — | 1 | 8.67 |
| CHEMBL475965 | — | — | 1 | 8.20 |
| CHEMBL477008 | — | — | 1 | 7.70 |
| CHEMBL458220 | — | — | 1 | 7.28 |
| CHEMBL458001 | — | — | 1 | 7.22 |
| CHEMBL474473 | — | — | 1 | 5.53 |
| CHEMBL474474 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458002 | — | Ki | = | 2.138 | nM | 8.67 |
| CHEMBL475965 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL477008 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL458220 | — | Ki | = | 52.48 | nM | 7.28 |
| CHEMBL458001 | — | Ki | = | 60.26 | nM | 7.22 |
| CHEMBL474473 | — | Ki | = | 2951.21 | nM | 5.53 |
| CHEMBL474474 | — | Ki | > | 7413.1 | nM | - |