Assay Detail
Binding
CHEMBL991391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]mesulergine from 5HT2C receptor expressed in HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.76 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458002 | — | — | 1 | 8.41 |
| CHEMBL458001 | — | — | 1 | 7.52 |
| CHEMBL458220 | — | — | 1 | 6.52 |
| CHEMBL474473 | — | — | 1 | 5.81 |
| CHEMBL477008 | — | — | 1 | 5.55 |
| CHEMBL474474 | — | — | 1 | - |
| CHEMBL475965 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458002 | — | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL458001 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL458220 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL474473 | — | Ki | = | 1548.82 | nM | 5.81 |
| CHEMBL477008 | — | Ki | = | 2818.38 | nM | 5.55 |
| CHEMBL474474 | — | Ki | > | 6025.6 | nM | - |
| CHEMBL475965 | — | Ki | > | 10000.0 | nM | - |