Assay Detail
Functional
CHEMBL991397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
29
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mas-related G-protein coupled receptor member X1 (CHEMBL5850) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 6.08 | 8.20 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475965 | — | — | 1 | 8.20 |
| CHEMBL477008 | — | — | 1 | 7.70 |
| CHEMBL474473 | — | — | 1 | 7.62 |
| CHEMBL474474 | — | — | 1 | 7.28 |
| CHEMBL475077 | — | — | 1 | 7.09 |
| CHEMBL448975 | — | — | 1 | 6.97 |
| CHEMBL475282 | — | — | 1 | 6.91 |
| CHEMBL458220 | — | — | 1 | 6.90 |
| CHEMBL449189 | — | — | 1 | 6.88 |
| CHEMBL477432 | — | — | 1 | 6.84 |
| CHEMBL451657 | — | — | 1 | 6.54 |
| CHEMBL476627 | — | — | 1 | 6.53 |
| CHEMBL474272 | — | — | 1 | 6.40 |
| CHEMBL477431 | — | — | 1 | 6.23 |
| CHEMBL506884 | — | — | 1 | 6.10 |
| CHEMBL474470 | — | — | 1 | 5.67 |
| CHEMBL517029 | — | — | 1 | 5.57 |
| CHEMBL458002 | — | — | 1 | 5.39 |
| CHEMBL476619 | — | — | 1 | 5.38 |
| CHEMBL450183 | — | — | 1 | 5.24 |
| CHEMBL500240 | — | — | 1 | 5.15 |
| CHEMBL477643 | — | — | 1 | 5.09 |
| CHEMBL458001 | — | — | 1 | 5.08 |
| CHEMBL457789 | — | — | 1 | 4.96 |
| CHEMBL457788 | — | — | 1 | 4.70 |
| CHEMBL514267 | — | — | 1 | 4.68 |
| CHEMBL456481 | — | — | 1 | 4.58 |
| CHEMBL499944 | — | — | 1 | 4.49 |
| CHEMBL474675 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475965 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL477008 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL474473 | — | EC50 | = | 23.99 | nM | 7.62 |
| CHEMBL474474 | — | EC50 | = | 52.48 | nM | 7.28 |
| CHEMBL475077 | — | EC50 | = | 81.28 | nM | 7.09 |
| CHEMBL448975 | — | EC50 | = | 107.15 | nM | 6.97 |
| CHEMBL475282 | — | EC50 | = | 123.03 | nM | 6.91 |
| CHEMBL458220 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL449189 | — | EC50 | = | 131.83 | nM | 6.88 |
| CHEMBL477432 | — | EC50 | = | 144.54 | nM | 6.84 |
| CHEMBL451657 | — | EC50 | = | 288.4 | nM | 6.54 |
| CHEMBL476627 | — | EC50 | = | 295.12 | nM | 6.53 |
| CHEMBL474272 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL477431 | — | EC50 | = | 588.84 | nM | 6.23 |
| CHEMBL506884 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL474470 | — | EC50 | = | 2137.96 | nM | 5.67 |
| CHEMBL517029 | — | EC50 | = | 2691.53 | nM | 5.57 |
| CHEMBL458002 | — | EC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL476619 | — | EC50 | = | 4168.69 | nM | 5.38 |
| CHEMBL450183 | — | EC50 | = | 5754.4 | nM | 5.24 |
| CHEMBL500240 | — | EC50 | = | 7079.46 | nM | 5.15 |
| CHEMBL477643 | — | EC50 | = | 8128.31 | nM | 5.09 |
| CHEMBL458001 | — | EC50 | = | 8317.64 | nM | 5.08 |
| CHEMBL457789 | — | EC50 | = | 10964.78 | nM | 4.96 |
| CHEMBL457788 | — | EC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL514267 | — | EC50 | = | 20892.96 | nM | 4.68 |
| CHEMBL456481 | — | EC50 | = | 26302.68 | nM | 4.58 |
| CHEMBL499944 | — | EC50 | = | 32359.37 | nM | 4.49 |
| CHEMBL474675 | — | Activity | - | — | - |