Assay Detail
Binding
CHEMBL991555
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Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Small conductance calcium-activated potassium channel protein 2 (CHEMBL4469) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.75 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476339 | — | — | 1 | 7.23 |
| CHEMBL489770 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476339 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL489770 | — | IC50 | = | 543.0 | nM | 6.26 |