Assay Detail
Binding
CHEMBL991599
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Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
9
Total Activities
7
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensin receptor 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.80 | 9.29 |
| Kd | 1 | 9.20 | 9.20 |
| Bmax | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443967 | — | — | 1 | 9.29 |
| CHEMBL342252 | — | — | 3 | 9.20 |
| CHEMBL407196 | NEUROTENSIN | — | 1 | 8.68 |
| CHEMBL507382 | — | — | 1 | 8.62 |
| CHEMBL503059 | — | — | 1 | 6.80 |
| CHEMBL508130 | — | — | 1 | 6.72 |
| CHEMBL2310906 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443967 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL342252 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL342252 | — | Kd | = | 0.63 | nM | 9.20 |
| CHEMBL407196 | NEUROTENSIN | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL507382 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL503059 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL508130 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL2310906 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL342252 | — | Bmax | = | 11.0 | pmol/mg | - |