Assay Detail
Functional
CHEMBL991605
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 in type O+ human erythrocytes after 48 hrs as reduced [3H]hypoxanthine uptake
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 5.87 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL508668 | — | — | 1 | 6.52 |
| CHEMBL507484 | — | — | 1 | 6.37 |
| CHEMBL501972 | — | — | 1 | 6.35 |
| CHEMBL452725 | — | — | 1 | 6.31 |
| CHEMBL444759 | — | — | 1 | 6.30 |
| CHEMBL502445 | — | — | 1 | 6.27 |
| CHEMBL449918 | — | — | 1 | 6.14 |
| CHEMBL448631 | — | — | 1 | 5.96 |
| CHEMBL504596 | — | — | 1 | 5.92 |
| CHEMBL499762 | — | — | 1 | 5.85 |
| CHEMBL508023 | — | — | 1 | 5.55 |
| CHEMBL509473 | — | — | 1 | 5.54 |
| CHEMBL509191 | — | — | 1 | 5.48 |
| CHEMBL503181 | — | — | 1 | 5.48 |
| CHEMBL500010 | — | — | 1 | 5.38 |
| CHEMBL510300 | — | — | 1 | 5.28 |
| CHEMBL231522 | — | — | 1 | 5.17 |
| CHEMBL499956 | — | — | 1 | - |
| CHEMBL442632 | — | — | 1 | - |
| CHEMBL448977 | — | — | 1 | - |
| CHEMBL448365 | — | — | 1 | - |
| CHEMBL509323 | — | — | 1 | - |
| CHEMBL452345 | — | — | 1 | - |
| CHEMBL508116 | — | — | 1 | - |
| CHEMBL453415 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL508668 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL507484 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL501972 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL452725 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL444759 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL502445 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL449918 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL448631 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL504596 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL499762 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL508023 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL509473 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL509191 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL503181 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL500010 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL510300 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL231522 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL499956 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL442632 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL448977 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL448365 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL509323 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL452345 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL508116 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL453415 | — | EC50 | > | 8000.0 | nM | - |