Assay Detail
Binding
CHEMBL991724
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Inhibition of baboon liver mitochondrial monoamine oxidase B using 50 uM of MMTP by spectrophotometry
17
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Papio |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.96 | 7.79 |
| Ki | 7 | 7.00 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522271 | — | — | 2 | 7.79 |
| CHEMBL522256 | — | — | 2 | 7.66 |
| CHEMBL489391 | — | — | 2 | 7.29 |
| CHEMBL489390 | — | — | 2 | 7.25 |
| CHEMBL483450 | — | — | 2 | 7.21 |
| CHEMBL483243 | — | — | 2 | 7.07 |
| CHEMBL483663 | — | — | 2 | 6.66 |
| CHEMBL446316 | — | — | 2 | 5.86 |
| CHEMBL483222 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522271 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL522256 | — | Ki | = | 21.9 | nM | 7.66 |
| CHEMBL522271 | — | IC50 | = | 28.4 | nM | 7.55 |
| CHEMBL522256 | — | IC50 | = | 37.9 | nM | 7.42 |
| CHEMBL489391 | — | Ki | = | 51.4 | nM | 7.29 |
| CHEMBL489390 | — | Ki | = | 55.6 | nM | 7.25 |
| CHEMBL483450 | — | Ki | = | 61.8 | nM | 7.21 |
| CHEMBL483243 | — | Ki | = | 84.3 | nM | 7.07 |
| CHEMBL489391 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL489390 | — | IC50 | = | 96.3 | nM | 7.02 |
| CHEMBL483450 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL483243 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL483663 | — | Ki | = | 221.1 | nM | 6.66 |
| CHEMBL483663 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL446316 | — | Ki | = | 1369.0 | nM | 5.86 |
| CHEMBL446316 | — | IC50 | = | 2371.0 | nM | 5.62 |
| CHEMBL483222 | — | IC50 | - | — | - |