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Assay Detail

CHEMBL991728

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of baboon liver mitochondrial monoamine oxidase B using 30 to 120 uM of MMTP by spectrophotometry
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Papio
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues.
Pretorius J, Malan SF, Castagnoli N, Bergh JJ, Petzer JP.
Bioorg Med Chem (2008) 16 : 8676 -8684
PubMed 18723354 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 4.33 4.76

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL522256 1 4.76
CHEMBL522271 1 4.72
CHEMBL484470 1 4.44
CHEMBL489390 1 4.38
CHEMBL489391 1 4.33
CHEMBL519984 1 4.26
CHEMBL483450 1 4.20
CHEMBL483243 1 4.09
CHEMBL21053 1 4.06
CHEMBL483662 1 4.01
CHEMBL483663 1 -
CHEMBL446316 1 -
CHEMBL483222 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL522256 Ki = 17200.0 nM 4.76
CHEMBL522271 Ki = 18900.0 nM 4.72
CHEMBL484470 Ki = 36000.0 nM 4.44
CHEMBL489390 Ki = 42100.0 nM 4.38
CHEMBL489391 Ki = 46400.0 nM 4.33
CHEMBL519984 Ki = 54600.0 nM 4.26
CHEMBL483450 Ki = 62700.0 nM 4.20
CHEMBL483243 Ki = 80600.0 nM 4.09
CHEMBL21053 Ki = 86200.0 nM 4.06
CHEMBL483662 Ki = 97600.0 nM 4.01
CHEMBL483663 Ki = 148600.0 nM -
CHEMBL446316 Ki = 1712000.0 nM -
CHEMBL483222 Ki = 2864000.0 nM -