Assay Detail
Binding
CHEMBL991892
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Binding affinity to GABAA alpha-4-beta-3-gamma-2 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA A receptor alpha-4/beta-3/gamma-2 (CHEMBL2111366) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.58 | 8.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471977 | — | — | 1 | 8.58 |
| CHEMBL45346 | — | — | 1 | - |
| CHEMBL394710 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471977 | — | Ki | = | 2.61 | nM | 8.58 |
| CHEMBL45346 | — | Ki | > | 300.0 | nM | - |
| CHEMBL394710 | — | Ki | > | 1500.0 | nM | - |