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Assay Detail

CHEMBL991977

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against uninfected PHA-stimulated human PBMC assessed as thymidine incorporation after 24 hrs by trypan blue exclusion method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type PBMC
Confidence 1 — Organism
Curated By Autocuration

Target

PBMC (CHEMBL613107)
Type CELL-LINE
Organism Homo sapiens

Publication

In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.
Lin YM, Anderson H, Flavin MT, Pai YH, Mata-Greenwood E, Pengsuparp T, Pezzuto JM, Schinazi RF, Hughes SH, Chen FC.
J Nat Prod (1997) 60 : 884 -888
PubMed 9322359 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 4.40 5.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL291426 HINOKIFLAVONE 1 5.05
CHEMBL65320 AGATHISFLAVONE 1 4.60
CHEMBL63354 AMENTOFLAVONE 1 4.46
CHEMBL63677 ROBUSTAFLAVONE 1 4.11
CHEMBL1215433 MORELLOFLAVONE 1 4.09
CHEMBL456859 1 4.06
CHEMBL129 ZIDOVUDINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL291426 HINOKIFLAVONE IC50 = 9000.0 nM 5.05
CHEMBL65320 AGATHISFLAVONE IC50 = 25000.0 nM 4.60
CHEMBL63354 AMENTOFLAVONE IC50 = 35000.0 nM 4.46
CHEMBL63677 ROBUSTAFLAVONE IC50 = 77000.0 nM 4.11
CHEMBL1215433 MORELLOFLAVONE IC50 = 82000.0 nM 4.09
CHEMBL456859 IC50 = 88000.0 nM 4.06
CHEMBL129 ZIDOVUDINE IC50 > 100000.0 nM -