Assay Detail
Functional
CHEMBL991983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HT29 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biomimetic cyclization of cnicin to malacitanolide, a cytotoxic eudesmanolide from Centaurea malacitana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.88 | 4.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1257707 | CNICIN | — | 1 | 4.88 |
| CHEMBL462826 | — | — | 1 | - |
| CHEMBL464125 | MALACITANOLIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1257707 | CNICIN | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL462826 | — | IC50 | = | 5.0 | ug.mL-1 | - |
| CHEMBL464125 | MALACITANOLIDE | IC50 | = | 0.12 | ug.mL-1 | - |