Assay Detail
Functional
CHEMBL992219
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Binding affinity to NK3 receptor in gerbil cortex at 10 mg/kg, po
3
Total Activities
3
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Gerbillinae |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New quinoline NK3 receptor antagonists with CNS activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.43 | 8.90 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| DOSE | DOSE | 10.0 | mg.kg-1 | — |
| ROUTE | ROUTE | - | — | Oral |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479463 | — | — | 1 | 8.90 |
| CHEMBL346178 | OSANETANT | 2.0 | 1 | 8.70 |
| CHEMBL10188 | TALNETANT | 2.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479463 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL346178 | OSANETANT | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL10188 | TALNETANT | Ki | = | 19.95 | nM | 7.70 |