Assay Detail
Binding
CHEMBL992463
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Displacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 I329G mutant expressed in HEK293 cells
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensin receptor 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 9.33 | 9.33 |
| Ki | 1 | 5.39 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342252 | — | — | 1 | 9.33 |
| CHEMBL2310906 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342252 | — | Kd | = | 0.47 | nM | 9.33 |
| CHEMBL2310906 | — | Ki | = | 4100.0 | nM | 5.39 |