Assay Detail
Binding
CHEMBL992479
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Inhibition of CDK4
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.24 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457887 | — | — | 1 | 6.85 |
| CHEMBL478409 | — | — | 1 | 6.70 |
| CHEMBL457888 | — | — | 1 | 6.68 |
| CHEMBL488436 | AZD-5438 | 1.0 | 1 | 6.35 |
| CHEMBL515854 | — | — | 1 | 6.31 |
| CHEMBL515839 | — | — | 1 | 6.28 |
| CHEMBL485618 | — | — | 1 | 5.89 |
| CHEMBL457979 | — | — | 1 | 5.82 |
| CHEMBL520187 | — | — | 1 | 5.25 |
| CHEMBL483590 | — | — | 1 | - |
| CHEMBL458547 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457887 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL478409 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL457888 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL488436 | AZD-5438 | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL515854 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL515839 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL485618 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL457979 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL520187 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL483590 | — | IC50 | > | 9000.0 | nM | - |
| CHEMBL458547 | — | IC50 | > | 8600.0 | nM | - |