Assay Detail
Functional
CHEMBL992481
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Antiproliferative activity against human LoVo cells assessed as BrdU incorporation after 48 hrs
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.84 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478409 | — | — | 1 | 6.51 |
| CHEMBL484555 | — | — | 1 | 6.21 |
| CHEMBL488436 | AZD-5438 | 1.0 | 1 | 6.20 |
| CHEMBL515854 | — | — | 1 | 6.16 |
| CHEMBL457887 | — | — | 1 | 6.05 |
| CHEMBL515839 | — | — | 1 | 5.92 |
| CHEMBL457888 | — | — | 1 | 5.92 |
| CHEMBL485618 | — | — | 1 | 5.82 |
| CHEMBL457979 | — | — | 1 | 5.82 |
| CHEMBL485619 | — | — | 1 | 5.75 |
| CHEMBL485240 | — | — | 1 | 5.75 |
| CHEMBL520187 | — | — | 1 | 5.40 |
| CHEMBL483590 | — | — | 1 | 5.22 |
| CHEMBL458547 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478409 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL484555 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL488436 | AZD-5438 | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL515854 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL457887 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL515839 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL457888 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL485618 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL457979 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL485619 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL485240 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL520187 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL483590 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL458547 | — | IC50 | = | 9200.0 | nM | 5.04 |