Assay Detail
Binding
CHEMBL992543
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant ITK by DELFIA assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Itk kinase inhibitors: initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.91 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483581 | — | — | 1 | 8.70 |
| CHEMBL460824 | — | — | 1 | 8.52 |
| CHEMBL485202 | — | — | 1 | 8.52 |
| CHEMBL485556 | — | — | 1 | 8.40 |
| CHEMBL485030 | — | — | 1 | 8.40 |
| CHEMBL485203 | — | — | 1 | 8.22 |
| CHEMBL485626 | — | — | 1 | 8.15 |
| CHEMBL462301 | — | — | 1 | 8.15 |
| CHEMBL519033 | — | — | 1 | 8.10 |
| CHEMBL457706 | — | — | 1 | 8.10 |
| CHEMBL458796 | — | — | 1 | 8.00 |
| CHEMBL460389 | — | — | 1 | 8.00 |
| CHEMBL484945 | — | — | 1 | 8.00 |
| CHEMBL484766 | — | — | 1 | 7.92 |
| CHEMBL457886 | — | — | 1 | 7.85 |
| CHEMBL462514 | — | — | 1 | 7.75 |
| CHEMBL457705 | — | — | 1 | 7.64 |
| CHEMBL517901 | — | — | 1 | 7.57 |
| CHEMBL485201 | — | — | 1 | 7.57 |
| CHEMBL490269 | — | — | 1 | 7.46 |
| CHEMBL485584 | — | — | 1 | 7.27 |
| CHEMBL485206 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483581 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL460824 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL485202 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL485556 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL485030 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL485203 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL485626 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL462301 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL519033 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL457706 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL458796 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL460389 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL484945 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL484766 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL457886 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL462514 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL457705 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL517901 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL485201 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL490269 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL485584 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL485206 | — | IC50 | = | 1900.0 | nM | 5.72 |