Assay Detail
Binding
CHEMBL992545
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Inhibition of IRK
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Itk kinase inhibitors: initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.79 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457886 | — | — | 1 | 6.96 |
| CHEMBL485202 | — | — | 1 | 6.92 |
| CHEMBL460389 | — | — | 1 | 6.50 |
| CHEMBL460824 | — | — | 1 | - |
| CHEMBL485203 | — | — | 1 | - |
| CHEMBL485206 | — | — | 1 | - |
| CHEMBL457705 | — | — | 1 | - |
| CHEMBL457706 | — | — | 1 | - |
| CHEMBL458796 | — | — | 1 | - |
| CHEMBL462301 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457886 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL485202 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL460389 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL460824 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL485203 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL485206 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL457705 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL457706 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL458796 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL462301 | — | IC50 | > | 10000.0 | nM | - |