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Assay Detail

CHEMBL992563

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of ITK by DELFIA assay
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Tyrosine-protein kinase ITK/TSK (CHEMBL2959) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk).
Moriarty KJ, Takahashi H, Pullen SS, Khine HH, Sallati RH, Raymond EL, Woska JR, Jeanfavre DD, Roth GP, Winters MP, Qiao L, Ryan D, DesJarlais R, Robinson D, Wilson M, Bobko M, Cook BN, Lo HY, Nemoto PA, Kashem MA, Wolak JP, White A, Magolda RL, Tomczuk B.
Bioorg Med Chem Lett (2008) 18 : 5545 -5549
PubMed 18819799 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 50 7.44 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL485607 — — 1 8.52
CHEMBL485591 — — 1 8.52
CHEMBL485031 — — 1 8.40
CHEMBL485556 — — 1 8.40
CHEMBL485555 — — 1 8.40
CHEMBL483403 — — 1 8.40
CHEMBL485232 — — 1 8.30
CHEMBL491076 — — 1 8.30
CHEMBL523633 — — 1 8.30
CHEMBL519347 — — 1 8.22
CHEMBL458787 — — 1 8.15
CHEMBL516958 — — 1 8.10
CHEMBL483397 — — 1 8.05
CHEMBL483763 — — 1 8.05
CHEMBL485233 — — 1 8.00
CHEMBL520312 — — 1 8.00
CHEMBL485565 — — 1 8.00
CHEMBL484940 — — 1 7.92
CHEMBL483764 — — 1 7.85
CHEMBL484767 — — 1 7.80
CHEMBL484390 — — 1 7.80
CHEMBL519698 — — 1 7.80
CHEMBL444151 — — 1 7.75
CHEMBL460824 — — 1 7.70
CHEMBL485402 — — 1 7.60
CHEMBL484395 — — 1 7.46
CHEMBL521468 — — 1 7.46
CHEMBL485564 — — 1 7.40
CHEMBL460823 — — 1 7.34
CHEMBL483602 — — 1 7.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL485607 — IC50 = 3.0 nM 8.52
CHEMBL485591 — IC50 = 3.0 nM 8.52
CHEMBL485556 — IC50 = 4.0 nM 8.40
CHEMBL485555 — IC50 = 4.0 nM 8.40
CHEMBL483403 — IC50 = 4.0 nM 8.40
CHEMBL485031 — IC50 = 4.0 nM 8.40
CHEMBL485232 — IC50 = 5.0 nM 8.30
CHEMBL491076 — IC50 = 5.0 nM 8.30
CHEMBL523633 — IC50 = 5.0 nM 8.30
CHEMBL519347 — IC50 = 6.0 nM 8.22
CHEMBL458787 — IC50 = 7.0 nM 8.15
CHEMBL516958 — IC50 = 8.0 nM 8.10
CHEMBL483397 — IC50 = 9.0 nM 8.05
CHEMBL483763 — IC50 = 9.0 nM 8.05
CHEMBL485565 — IC50 = 10.0 nM 8.00
CHEMBL520312 — IC50 = 10.0 nM 8.00
CHEMBL485233 — IC50 = 10.0 nM 8.00
CHEMBL484940 — IC50 = 12.0 nM 7.92
CHEMBL483764 — IC50 = 14.0 nM 7.85
CHEMBL484767 — IC50 = 16.0 nM 7.80
CHEMBL484390 — IC50 = 16.0 nM 7.80
CHEMBL519698 — IC50 = 16.0 nM 7.80
CHEMBL444151 — IC50 = 18.0 nM 7.75
CHEMBL460824 — IC50 = 20.0 nM 7.70
CHEMBL485402 — IC50 = 25.0 nM 7.60
CHEMBL484395 — IC50 = 35.0 nM 7.46
CHEMBL521468 — IC50 = 35.0 nM 7.46
CHEMBL485564 — IC50 = 40.0 nM 7.40
CHEMBL460823 — IC50 = 46.0 nM 7.34
CHEMBL483602 — IC50 = 56.0 nM 7.25
CHEMBL458797 — IC50 = 59.0 nM 7.23
CHEMBL490872 — IC50 = 61.0 nM 7.21
CHEMBL483181 — IC50 = 68.0 nM 7.17
CHEMBL484934 — IC50 = 73.0 nM 7.14
CHEMBL461029 — IC50 = 76.0 nM 7.12
CHEMBL522085 — IC50 = 89.0 nM 7.05
CHEMBL516173 — IC50 = 150.0 nM 6.82
CHEMBL516012 — IC50 = 220.0 nM 6.66
CHEMBL485390 — IC50 = 250.0 nM 6.60
CHEMBL519697 — IC50 = 270.0 nM 6.57
CHEMBL458798 — IC50 = 320.0 nM 6.50
CHEMBL484546 — IC50 = 520.0 nM 6.28
CHEMBL489266 — IC50 = 690.0 nM 6.16
CHEMBL489460 — IC50 = 2000.0 nM 5.70
CHEMBL484941 — IC50 = 3300.0 nM 5.48
CHEMBL521484 — IC50 = 4500.0 nM 5.35
CHEMBL519183 — IC50 = 4500.0 nM 5.35
CHEMBL458604 — IC50 > 20000.0 nM -
CHEMBL485399 — IC50 > 10000.0 nM -
CHEMBL485378 — IC50 > 20000.0 nM -