Assay Detail
Binding
CHEMBL992567
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Inhibition of IRK
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.25 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483397 | — | — | 1 | 7.02 |
| CHEMBL485555 | — | — | 1 | 6.90 |
| CHEMBL485564 | — | — | 1 | 6.85 |
| CHEMBL519698 | — | — | 1 | 6.63 |
| CHEMBL520312 | — | — | 1 | 6.26 |
| CHEMBL483602 | — | — | 1 | 6.26 |
| CHEMBL485233 | — | — | 1 | 6.26 |
| CHEMBL485232 | — | — | 1 | 6.07 |
| CHEMBL485565 | — | — | 1 | 5.75 |
| CHEMBL483403 | — | — | 1 | 5.41 |
| CHEMBL485402 | — | — | 1 | 5.31 |
| CHEMBL485607 | — | — | 1 | - |
| CHEMBL484941 | — | — | 1 | - |
| CHEMBL484940 | — | — | 1 | - |
| CHEMBL521468 | — | — | 1 | - |
| CHEMBL485556 | — | — | 1 | - |
| CHEMBL485399 | — | — | 1 | - |
| CHEMBL484546 | — | — | 1 | - |
| CHEMBL521484 | — | — | 1 | - |
| CHEMBL485390 | — | — | 1 | - |
| CHEMBL483181 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483397 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL485555 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL485564 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL519698 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL520312 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL483602 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL485233 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL485232 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL485565 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL483403 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL485402 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL485607 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL484941 | — | IC50 | - | — | - | |
| CHEMBL484940 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL521468 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL485556 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL485399 | — | IC50 | - | — | - | |
| CHEMBL484546 | — | IC50 | - | — | - | |
| CHEMBL521484 | — | IC50 | - | — | - | |
| CHEMBL485390 | — | IC50 | - | — | - | |
| CHEMBL483181 | — | IC50 | > | 10000.0 | nM | - |