Assay Detail
Binding
CHEMBL992575
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ITK expressed in chicken DT40 cells assessed as B cell receptor-stimulated calcium influx by FLIPR assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | DT40 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.28 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483403 | — | — | 1 | 6.50 |
| CHEMBL485031 | — | — | 1 | 6.29 |
| CHEMBL485564 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483403 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL485031 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL485564 | — | IC50 | = | 900.0 | nM | 6.05 |