Assay Detail
Functional
CHEMBL992589
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Inhibition of IL2 production in PHA-stimulated human PBMC after 24 hrs by ELISA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies of imidazo[1,2-c]pyrimidine derivatives as potent and orally effective Syk family kinases inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.10 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.80 |
| CHEMBL475609 | — | — | 1 | 7.34 |
| CHEMBL485204 | — | — | 1 | 7.24 |
| CHEMBL475575 | — | — | 1 | 7.12 |
| CHEMBL458973 | — | — | 1 | 6.82 |
| CHEMBL459147 | — | — | 1 | 6.70 |
| CHEMBL459146 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL475609 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL485204 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL475575 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL458973 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL459147 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL459146 | — | IC50 | = | 200.0 | nM | 6.70 |