Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL992668

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Caenorhabditis elegans carbonic anhydrase 4b by CO2 hydration assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Caenorhabditis elegans
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.
Güzel O, Innocenti A, Hall RA, Scozzafava A, Mühlschlegel FA, Supuran CT.
Bioorg Med Chem (2009) 17 : 3212 -3215
PubMed 19201197 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 7.40 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL476599 1 8.22
CHEMBL477016 1 8.19
CHEMBL476395 1 8.00
CHEMBL476813 1 8.00
CHEMBL476609 1 7.94
CHEMBL475973 1 7.91
CHEMBL514992 1 7.90
CHEMBL475972 1 7.88
CHEMBL515010 1 7.87
CHEMBL20 ACETAZOLAMIDE 4.0 1 7.46
CHEMBL18 ETHOXZOLAMIDE 4.0 1 7.40
CHEMBL500025 1 6.58
CHEMBL476815 1 6.58
CHEMBL446212 1 6.49
CHEMBL515782 1 6.48
CHEMBL262628 1 6.47
CHEMBL515310 1 6.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL476599 Ki = 6.0 nM 8.22
CHEMBL477016 Ki = 6.5 nM 8.19
CHEMBL476395 Ki = 9.9 nM 8.00
CHEMBL476813 Ki = 10.1 nM 8.00
CHEMBL476609 Ki = 11.5 nM 7.94
CHEMBL475973 Ki = 12.2 nM 7.91
CHEMBL514992 Ki = 12.5 nM 7.90
CHEMBL475972 Ki = 13.3 nM 7.88
CHEMBL515010 Ki = 13.4 nM 7.87
CHEMBL20 ACETAZOLAMIDE Ki = 35.0 nM 7.46
CHEMBL18 ETHOXZOLAMIDE Ki = 40.0 nM 7.40
CHEMBL500025 Ki = 260.0 nM 6.58
CHEMBL476815 Ki = 260.0 nM 6.58
CHEMBL446212 Ki = 326.0 nM 6.49
CHEMBL515782 Ki = 330.0 nM 6.48
CHEMBL262628 Ki = 339.0 nM 6.47
CHEMBL515310 Ki = 372.0 nM 6.43