Assay Detail
Binding
CHEMBL992739
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Binding affinity to human cloned 5HT6 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.63 | 8.00 |
Compounds Tested
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL42 | CLOZAPINE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL708 | ZIPRASIDONE | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL476108 | — | Ki | = | 295.9 | nM | 6.53 |
| CHEMBL716 | QUETIAPINE | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL85 | RISPERIDONE | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 6000.0 | nM | 5.22 |