Assay Detail
Binding
CHEMBL992760
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]flumazenil from human recombinant GABAA alpha-2-beta-2-gamma-2S receptor expressed in HEK293 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Affinity of 3-acyl substituted 4-quinolones at the benzodiazepine site of GABA(A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.45 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469477 | — | — | 1 | 9.40 |
| CHEMBL488283 | — | — | 1 | 9.09 |
| CHEMBL471551 | — | — | 1 | 8.80 |
| CHEMBL488284 | — | — | 1 | 8.77 |
| CHEMBL487685 | — | — | 1 | 8.57 |
| CHEMBL488285 | — | — | 1 | 7.80 |
| CHEMBL488286 | — | — | 1 | 7.66 |
| CHEMBL506314 | — | — | 1 | 7.51 |
| CHEMBL470283 | — | — | 1 | - |
| CHEMBL381059 | — | — | 1 | - |
| CHEMBL206540 | — | — | 1 | - |
| CHEMBL487867 | — | — | 1 | - |
| CHEMBL487688 | — | — | 1 | - |
| CHEMBL487687 | — | — | 1 | - |
| CHEMBL487686 | — | — | 1 | - |
| CHEMBL520411 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469477 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL488283 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL471551 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL488284 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL487685 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL488285 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL488286 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL506314 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL470283 | — | Ki | - | — | - | |
| CHEMBL381059 | — | Ki | - | — | - | |
| CHEMBL206540 | — | Ki | - | — | - | |
| CHEMBL487867 | — | Ki | - | — | - | |
| CHEMBL487688 | — | Ki | - | — | - | |
| CHEMBL487687 | — | Ki | - | — | - | |
| CHEMBL487686 | — | Ki | - | — | - | |
| CHEMBL520411 | — | Ki | - | — | - |