Assay Detail
Binding
CHEMBL992764
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Inhibition of PARP2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.22 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452801 | — | — | 1 | 8.70 |
| CHEMBL460267 | — | — | 1 | 8.52 |
| CHEMBL452800 | — | — | 1 | 8.30 |
| CHEMBL527654 | — | — | 1 | 7.96 |
| CHEMBL518484 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452801 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL460267 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL452800 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL527654 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL518484 | — | Ki | = | 24.0 | nM | 7.62 |