Assay Detail
Binding
CHEMBL992766
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Inhibition of PARP1 in human C41 cells
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | C41 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 41 | 7.69 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460474 | — | — | 1 | 9.00 |
| CHEMBL453059 | — | — | 1 | 8.70 |
| CHEMBL500298 | — | — | 1 | 8.52 |
| CHEMBL452800 | — | — | 1 | 8.52 |
| CHEMBL450698 | — | — | 1 | 8.40 |
| CHEMBL452801 | — | — | 1 | 8.40 |
| CHEMBL452025 | — | — | 1 | 8.30 |
| CHEMBL512213 | — | — | 1 | 8.22 |
| CHEMBL453060 | — | — | 1 | 8.22 |
| CHEMBL460261 | — | — | 1 | 8.05 |
| CHEMBL454180 | — | — | 1 | 8.05 |
| CHEMBL452539 | — | — | 1 | 7.92 |
| CHEMBL507699 | — | — | 1 | 7.92 |
| CHEMBL508421 | — | — | 1 | 7.89 |
| CHEMBL488664 | — | — | 1 | 7.85 |
| CHEMBL453997 | — | — | 1 | 7.82 |
| CHEMBL451757 | — | — | 1 | 7.82 |
| CHEMBL452785 | — | — | 1 | 7.80 |
| CHEMBL488831 | — | — | 1 | 7.80 |
| CHEMBL488830 | — | — | 1 | 7.75 |
| CHEMBL504878 | — | — | 1 | 7.75 |
| CHEMBL513621 | — | — | 1 | 7.68 |
| CHEMBL459853 | — | — | 1 | 7.68 |
| CHEMBL511050 | — | — | 1 | 7.66 |
| CHEMBL488665 | — | — | 1 | 7.62 |
| CHEMBL488497 | — | — | 1 | 7.54 |
| CHEMBL445724 | — | — | 1 | 7.52 |
| CHEMBL488053 | — | — | 1 | 7.51 |
| CHEMBL451756 | — | — | 1 | 7.12 |
| CHEMBL81723 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460474 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL453059 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL452800 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL500298 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL450698 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL452801 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL452025 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL512213 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL453060 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL460261 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL454180 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL452539 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL507699 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL508421 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL488664 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL453997 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL451757 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL452785 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL488831 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL504878 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL488830 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL513621 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL459853 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL511050 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL488665 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL488497 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL445724 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL488053 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL451756 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL81723 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL460060 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL513446 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL488496 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL460260 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL460267 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL505655 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL444135 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL527654 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL488052 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL460259 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL518484 | — | EC50 | > | 1000.0 | nM | - |