Assay Detail
Binding
CHEMBL992850
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Displacement of [3H]flumazenil from GABAA receptor in rat cortical membrane
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Affinity of 3-acyl substituted 4-quinolones at the benzodiazepine site of GABA(A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 8.66 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469477 | — | — | 1 | 9.77 |
| CHEMBL488283 | — | — | 1 | 9.66 |
| CHEMBL487687 | — | — | 1 | 9.64 |
| CHEMBL487686 | — | — | 1 | 9.57 |
| CHEMBL488284 | — | — | 1 | 9.38 |
| CHEMBL487685 | — | — | 1 | 9.28 |
| CHEMBL470285 | — | — | 1 | 9.27 |
| CHEMBL470284 | — | — | 1 | 9.06 |
| CHEMBL471551 | — | — | 1 | 9.05 |
| CHEMBL471552 | — | — | 1 | 9.01 |
| CHEMBL520411 | — | — | 1 | 9.00 |
| CHEMBL488286 | — | — | 1 | 8.89 |
| CHEMBL381059 | — | — | 1 | 8.85 |
| CHEMBL487688 | — | — | 1 | 8.82 |
| CHEMBL527430 | — | — | 1 | 8.68 |
| CHEMBL470283 | — | — | 1 | 8.66 |
| CHEMBL488285 | — | — | 1 | 8.60 |
| CHEMBL488820 | — | — | 1 | 8.60 |
| CHEMBL506314 | — | — | 1 | 8.10 |
| CHEMBL487867 | — | — | 1 | 7.77 |
| CHEMBL488819 | — | — | 1 | 7.75 |
| CHEMBL447137 | — | — | 1 | 7.72 |
| CHEMBL206540 | — | — | 1 | 7.70 |
| CHEMBL442825 | — | — | 1 | 7.55 |
| CHEMBL486441 | — | — | 1 | 7.52 |
| CHEMBL470081 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469477 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL488283 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL487687 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL487686 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL488284 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL487685 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL470285 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL470284 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL471551 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL471552 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL520411 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL488286 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL381059 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL487688 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL527430 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL470283 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL488285 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL488820 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL506314 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL487867 | — | Ki | = | 17.1 | nM | 7.77 |
| CHEMBL488819 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL447137 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL206540 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL442825 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL486441 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL470081 | — | Ki | = | 69.0 | nM | 7.16 |